Drugs & Vitamins

Septra Injection Active Ingredients: Sulfamethoxazole and Trimethoprim Injection Representative Names: Bactrim Injection, SMX-TMP Injection, Septra Injection, TMP-SMX Injection, co-trimoxazole injection What is sulfamethoxazole; trimethoprim injection? What should I tell my health care provider before I take this medicine? How should I use this medicine? What if I miss a dose? What drug(s) may interact with sulfamethoxazole; trimethoprim? What side effects may I notice from receiving sulfamethoxazole; trimethoprim? What should I watch for while taking sulfamethoxazole; trimethoprim? Where can I keep my medicine? What is sulfamethoxazole; trimethoprim injection? (Back to top) SULFAMETHOXAZOLE; TRIMETHOPRIM or SMX-TMP (Septra®, Co-Trimoxazole, and others) is a combination of two antibiotics. The injection is used to treat severe infections of the urinary tract, infection of the intestines, and Pneumocystis carinii pneumonia in AIDS or cancer patients. A generic injection is available. What should I tell my health care provider before I take this medicine? (Back to top) They need to know if you have any of these conditions: •anemia or other blood disorders •high blood levels of potassium •kidney disease •liver disease •porphyria •glucose-6-phosphate dehydrogenase (G6PD) deficiency •an unusual or allergic reaction to sulfamethoxazole or other sulfa antibiotics, trimethoprim, furosemide or thiazide diuretics (water pills), oral diabetes medicines, or other medicines, foods, dyes, or preservatives •pregnant or trying to get pregnant •breast-feeding How should I use this medicine? (Back to top) SMX-TMP injection is for slow infusion into a vein. Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. What if I miss a dose? (Back to top) If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses. What drug(s) may interact with sulfamethoxazole; trimethoprim? (Back to top) •amiloride •cyclosporine •dapsone •digoxin •divalproex •dofetilide •doxercalciferol •medicines for diabetes •methenamine •methotrexate •metronidazole •phenytoin •potassium salts (potassium chloride, potassium phosphate) •procainamide •pyrimethamine •rifampin •some medicines used to treat blood pressure and/or heart failure (ACE inhibitors such as benazepril, enalapril, lisinopril, moexipril, quinapril, ramipril, and others) •spironolactone •sulfinpyrazone •triamterene •trimetrexate •valproic acid •warfarin Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines. What side effects may I notice from receiving sulfamethoxazole; trimethoprim? (Back to top) Elderly patients, and AIDS patients being treated for Pneumocystis carinii, are more likely to get serious side effects from SMX-TMP. Side effects that you should report to your prescriber or health care professional as soon as possible: •anemia or other blood disorders •allergic reactions •bluish fingernails or lips •difficulty breathing •fast or irregular heartbeat, palpitations, chest pain •fever or chills, sore throat •increased sensitivity to the sun or ultraviolet light •joint aches or pains •lower back pain •muscle aches or pains •pain or difficulty passing urine •pain, swelling and irritation at the injection site •redness, blistering, peeling or loosening of the skin, including inside the mouth •skin rash, hives, or itching •unusual bleeding or bruising •unusual weakness or tiredness •yellowing of the eyes or skin Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): •diarrhea •dizziness •headache •loss of appetite •nausea, vomiting What should I watch for while taking sulfamethoxazole; trimethoprim? (Back to top) Tell your prescriber or health care professional if your symptoms do not improve in 2 to 3 days. You may get dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Keep out of the sun, or wear protective clothing outdoors and use a sunscreen. Do not use sun lamps or sun tanning beds or booths. Drink several glasses of water a day. This will help to reduce possible kidney problems. Where can I keep my medicine? (Back to top) Keep out of the reach of children. Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F); do not refrigerate. Protect from light and moisture. Throw away any unused medicine after the expiration date. Last Updated:09/01/2005 CLINICAL PHARMACOLOGY© GOLD STANDARD MULTIMEDIA INC, ALL RIGHTS RESERVED

Note: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It should not be construed to indicate that the use of the product is safe, appropriate, or effective for you. Consult your healthcare professional before taking the product.